• Advancing multimer analysis of von Willebrand factor by single-molecule AFM imaging. Löf A, König G, Schneppenheim S, Schneppenheim R, Benoit M, Budde U, Müller JP, Brehm MA,  PLOS One, 2019 Jan 15;14(1):e0210963.



  • Interaction of von Willebrand factor domains with collagen investigated by single molecule force spectroscopy. Posch S, Obser T, König G, Schneppenheim R, Tampé R, Hinterdorfer P. J Chem Phys. 2018 Mar 28;148(12):123310. doi: 10.1063/1.5007313.



  • Mutual A domain interactions in the force sensing protein von Willebrand factor. Posch S, Aponte-Santamaría C, Schwarzl R, Karner A, Radtke M, Gräter F, Obser T, König G, Brehm MA, Gruber HJ, Netz RR, Baldauf C, Schneppenheim R, Tampé R, Hinterdorfer P. J Struct Biol. 2017 Jan;197(1):57-64.



  • Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer interaction. Müller JP, Mielke S, Löf A, Obser T, Beer C, Bruetzel LK,  Pippig DA, Vanderlinden W, Lipfert J, Schneppenheim R, Benoit M. PNAS 2016, 113(5),1208-1213, doi: 10.1073/pnas.1516214113

  • pH-Dependent Interactions in Dimers Govern the Mechanics and Structure of von Willebrand Factor. Müller JP,  Löf A, Mielke S, Obser T, Bruetzel LK, Vanderlinden W, Lipfert J, Schneppenheim R, Benoit M,  Biophysical Journal. (2016) 111(2), 312-322

  • Single molecule force spectroscopy data and BD- and MD simulations on the blood protein von Willebrand factor. Posch S, Aponte-Santamaría C, Schwarzl R, Karner A, Radtke M, Gräter F, Obser T, König G, Brehm MA, Gruber HJ, Netz RR, Baldauf C, Schneppenheim R, Tampé R, Hinterdorfer P. Data Brief. 2016 Jul 21;8:1080-7. doi: 10.1016/j.dib.2016.07.031. eCollection 2016 Sep.



  • Force-Sensitive Autoinhibition of the von Willebrand Factor Is Mediated by Interdomain Interactions. Aponte-Santamaría C, Huck V, Posch S, Bronowska AK, Grässle S, Brehm MA, Obser T, Schneppenheim R, Hinterdorfer P, Schneider SW, Baldauf C Gräter F.  Biophysical Journal (2015) 108(9): 2312-2321

  • Collagen Surface Functionalization - A New Strategy for Molecular Recognition Force Spectroscopy. Posch S. Imaging & Microscopy. (2015)17 March 2015(1)

  • Mechanosensitive Von Willebrand Factor Protein-Protein Interactions Regulate Hemostasis. Aponte-Santamaría C, Huck V, Posch S, Bronowska AK, Grässle S, Brehm AM, Obser T, Schneppenheim R, Hinterdorfer P, Schneider SW, Baldauf C, Gräter F. Biophys J. (2015) 108 (2): 505a.



  • VWF–Collagen Interactions Studied with Single Molecule Force Spectroscopy. Posch S, Obser T, Brehm AM, Gruber HJ, Schneppenheim R, Tampé R, Hinterdorfer P. Biophys J. 2014;106 (2):450a.



  • Activation induced morphological changes and integrin αIIbβ3 activity of living platelets. Posch S, Neundlinger I, Leitner M, Siostrzonek P, Panzer S, Hinterdorfer P, Ebner A. Methods. 2013; 60 (2): 179-185

  • A practical guide to quantify cell adhesion using single-cell force spectroscopy. Friedrichs J, Legate KR, Schubert R, Bharadwaj M, Werner C, Müller DJ, Benoit M. Methods. 2013; 60 (2):169-78

  • Probing the interaction forces of prostate cancer cells with collagen I and bone marrow derived stem cells on the single cell level. Sarıısık E, Docheva D, Padula D, Popov C, Opfer J, Schieker M, Clausen-Schumann H, Benoit M.  PLoS One. 2013; 8(3)

  • Exponential Size Distribution of von Willebrand Factor. Lippok S, Obser T, Müller JP, Stierle VK, Benoit M, Budde U, Schneppenheim R, Rädler J. Biophysical Journal. 2013, 105(5):1208-1216

  • Nanomapping of CD1d–glycolipid complexes on THP1 cells by using simultaneous topography and recognition imaging.

  • Posch, S., M. Brehm, T. Obser, R. Tampè, R. Schneppenheim and P. Hinterdorfer (2013). "Biophysical properties of VWF in single molecule force spectroscopy." European Biophysical Journal 42, July 2013



  • Lamprecht, C., N. Gierlinger, E. Heister, B. Unterauer, B. Plochberger, M. Brameshuber, P. Hinterdorfer, S. Hild, and A. Ebner, Mapping the intracellular distribution of carbon nanotubes after targeted delivery to carcinoma cells using confocal Raman imaging as a label-free technique,  Journal of Physics-Condensed Matter, Volume 24, Issue 16, Article Number: 164206, 25 April 2012.

  • Schlapak, R., J. Danzberger, T. Haselgrubler, P. Hinterdorfer, F. Schaffler, and S. Howorka, Painting with biomolecules at the nanoscale: biofunctionalization with tunable surface densities,  Nano Letters, Volume12, Issue 4, pp: 1983-1989, April 2012.

  • Schlapak, R., J. Danzberger, D. Armitage, D. Morgan, A. Ebner, P. Hinterdorfer, P. Pollheimer, H. J. Gruber, F. Schaffler, and S. Howorka, Nanoscale DNA tetrahedra improve biomolecular recognition on patterned surfaces, Small, Volume: 8, Issue: 1, pp: 89-97, 9 January 2012.

  • Sekot, G., G. Posch, Y. J. Oh, S. Zayni, H. F. Mayer, D. Pum, P. Messner, P. Hinterdorfer, and C. Schaffer, Analysis of the cell surface layer ultrastructure of the oral pathogen Tannerella forsythia, Archives of Microbiology, 2012, Volume194, Issue 6, pp. 525-539. 

  • Wildling L, Rankl C, Haselgrübler T, Gruber HJ, Holy M, Newman AH, Zou M-F, Zhu R, Freissmuth M, Sitte, HH, Hinterdorfer P, Probing the binding pocket of the serotonin transporter by single molecular force spectroscopy on living cells, Journal of Biological Chemistry, Volume 287, Issue 1, pp: 105-113. Published: 2 January 2012

  • Mahut, M., M. Leitner, A. Ebner, M. Lammerhofer, P. Hinterdorfer, and W. Lindner, Time-resolved chloroquine-induced relaxation of supercoiled plasmid DNA,  Analytical and Bioanalytical Chemistry, Volume 402, Issue 1, pp: 373-380, January 2012.

  • Mahut, M., E. Haller, P. Ghazidezfuli, M. Leitner, A. Ebner, P. Hinterdorfer, W. Lindner, and M. Lammerhofer, Topology-selective chromatography reveals plasmid supercoiling shifts during fermentation and allows rapid and efficient preparation of topoisomers, Angewandte Chemie-International Edition, Volume 51, Issue 1, pp: 267-270, 2012.



  • Riet, J., A. J. Katan, C. Rankl, S. W. Stahl, A. M. van Buul, I. Y. Phang, A. Gomez-Casado, P. Schon, J. W. Gerritsen, A. Cambi, A. E. Rowan, G. J. Vancso, P. Jonkheijm, J. Huskens, T. H. Oosterkamp, H. Gaub, P. Hinterdorfer, C. G. Figdor, and S. SpellerInterlaboratory round robin on cantilever calibration for AFM force spectroscopy, Ultramicroscopy, Volume 111, Issue12, pp:1659-1669. December 2011.

  • Rico, F., A. Oshima, P. Hinterdorfer, Y. Fujiyoshi, and S. Scheuring, Two-dimensional kinetics of    inter-connexin interactions from single-molecule force spectroscopy, Journal of Molecular Biology, Volume 412, Issue 1, pp: 72-79. 9 September 2011.

  • Leitner M, Mitchell N, Kastner M, Schlapak R, Gruber HJ, Hinterdorfer P, Howorka S, Ebner A, Single-Molecule AFM Characterization of Individual Chemically Tagged DNA Tetrahedra, ACS Nano, Volume 5, Issue 9, pp: 7048-7054.

  • Riihimaki, T. A., S. Hiltunen, M. Rangl, H. R. Nordlund, J. A. Maatta, A. Ebner, P. Hinterdorfer, M. S. Kulomaa, K. Takkinen, and V. P. Hytonen, Modification of the loops in the ligand-binding site turns avidin into a steroid-binding protein, BMC Biotechnology, Volume11, Article Number: 64. 9 June 2011.

  • Wildling L, Unterauer B, Zhu R, Rupprecht A, Haselgrübler T, Rankl C, Ebner A, Vater D, Pollheimer P, Pohl E, Hinterdorfer P, Gruber HJ, Linking of sensor molecules with amino groups to aminofunctionalized AFM tips, Bioconjugate Chem. 22:1239-1248, 2011.

  • Rankl, C., L. Wildling, I. Neundlinger, F. Kienberger, H. Gruber, D. Blaas, and P. Hinterdorfer, Determination of the kinetic on- and off-rate of single virus-cell interactions, Methods Mol Biol 736:197-210, 2011.

  • Oliveira, H., M. Rangl, A. Ebner, B. Mayer, P. Hinterdorfer, and A. P. Pego, Molecular recognition force spectroscopy: a new tool to tailor targeted nanoparticles, Small 7:1236-1241, 2011.

  • Oh, Y. J., H. P. Huber, M. Hochleitner, M. Duman, B. Bozna, M. Kastner, F. Kienberger, and P. Hinterdorfer, High-frequency electromagnetic dynamics properties of THP1 cells using scanning microwave microscopy, Ultramicroscopy 111:1625-1629, 2011.

  • Krenn, B. M., Egorov, A., Romanovskaya-Romanko, E., Wolschek, M., Nakowitsch, S., Ruthsatz, T., Kiefmann, B., Morokutti, A., Humer, J., Geiler, J., Cinatl, J., Michaelis, M., Wressnigg, N., Sturlan, S., Ferko, B., Batishchev, O. V., Indenbom, A. V., Zhu, R., Kastner, M., Hinterdorfer, P., Kiselev, O., Muster, T., Romanova, J, Single HA2 Mutation Increases the Infectivity and Immunogenicity of a Live Attenuated H5N1 Intranasal Influenza Vaccine Candidate Lacking NS1, PLoS ONE 6, 2011.

  • Humer, I., Bethgea, O., Bodnarchukb, M., Kovalenkob, M., Yaremab, M., Heissb, W., Huber, H. P., Hochleitner, M., Hinterdorfer, P., Kienberger, F., Smoliner, J. Scanning Microwave Microscopy and Scanning Capacitance Microscopy on colloidal nanocrystals, J. Appl. Phys., 109(6):064313-064316, 2011.

  • Neundlinger, I., A. Poturnayova, I. Karpisova, C. Rankl, P. Hinterdorfer, M. Snejdarkova, T. Hianik, and A. Ebner,Characterization of enhanced monovalent and bivalent thrombin DNA aptamer binding using single molecule force spectroscopy, Biophys J 101:1781-1787, 2011.

  • Creasey, R., S. Sharma, C. T. Gibson, J. E. Craig, A. Ebner, T. Becker, P. Hinterdorfer, and N. H. Voelcker, Atomic force microscopy-based antibody recognition imaging of proteins in the pathological deposits in pseudoexfoliation syndrome, Ultramicroscopy 111:1055-1061, 2011.

  • Bozna, B. L., P. Polzella, C. Rankl, R. Zhu, M. Salio, D. Shepherd, M. Duman, V. Cerundolo, and P. Hinterdorfer, Binding strength and dynamics of invariant natural killer cell T cell receptor/CD1d-glycosphingolipid interaction on living cells by single molecule force spectroscopy, J Biol Chem 286:15973-15979, 2011.

  • Ahmad, S. F., L. A. Chtcheglova, B. Mayer, S. A. Kuznetsov, and P. Hinterdorfer, Nanosensing of Fcgamma receptors on macrophages, Anal Bioanal Chem 399:2359-2367, 2011.

2005 bis 2008 (Benoit)
  • Lugmaier RA, Hugel T, Benoit M, Gaub HE. Phase contrast and DIC illumination for AFM hybrids. / Ultramicroscopy. 2005; 104: 255-60. 

  • Lugmaier R, Schedin S, Kühner F, Benoit M. Dynamic restacking of Escherichia Coli P-pili. / European Biophysics Journal. 2008; 37: 111-20. 

  • Pamir E, George M, Fertig N, Benoit M. Planar patch-clamp force microscopy on living cells. / Ultramicroscopy. 2008; 108: 552-7. 

  • Schmitz J, Benoit M, Gottschalk K-E. The Viscoelasticity of Membrane Tethers and Its Importance for Cell Adhesion. / Biophysical Journal. 2008; 95: 1448-59.