1st international SHENC Symposium  

Function of von Willebrand factor in primary and secondary hemostasis

  September 13th to 15th, 2015  


City of Hamburg / Germany


Website (english): HERE / Website (german): HERE

  Final scientific program  
Schedule Scientific program
September 13th, 2015  
4:00-8:00 pm Registration
6:00-8:00 pm Welcome and get-together
September 14th, 2015  
9:00-10:30 am Collective networks under flow – I –
R. Netz
M. Schneider: From single molecules to collective networks. Towards a physical foundation of thrombosis.
E. Westein: Bio-mechanics of thrombus formation under complex shear stress conditions.
A. Alexander-Katz: Why is VWF so special? A physics journey into blood plugging.
11:00-12:30 pm Collective networks under flow – II –
M. Schneider
R. Netz: Collective effects of catch and slip bonds under shear.
A. Reininger: Is bigger better? The function of ultralarge VWF multimers visualized in whole blood flow.
G. Gompper: Margination of von Willebrand factor and platelets in capillary blood flow.
12:30-2:30 pm Lunch and scientific poster presentations
2:30-4:00 pm Structure and function
C. Baldauf
T. Springer: VWF, Jedi knight of the bloodstream.
J. Eikenboom: A nanoscopic view on von Willebrand factor structures.
M. Wilmanns: Mechanisms of molecular elasticity in stretchable filament proteins.
4:30-6:00 pm Mechanics
G. Gompper
M. Benoit / P. Hinterdorfer: Inter- and intramolecular interactions of VWF studied on the single molecule level.
C.-H. Kiang: Mechanical activation of multimeric forms of von Willebrand factor.
F. Gräter: Molecular mechanisms of force-sensing in VWF.
September 15th, 2015  
9:00-10:30 am VWF interactions
F. Gräter
W. Thomas: Regulation of binding of the VWF A1 domain to platelet GPIb in flow conditions.
F. Hansen: Solution structure of the major factor VIII binding region on von Willebrand factor.
M. Auton: Misfolding the platelet hook of von Willebrand factor fishing lines.
11:00-12:30 pm VWF in hemostasis
S. Schneider
C. Denis: Von Willebrand factor clearance mechanisms.
K. Preissner: Extracellular nucleic acids as new risk factors for thrombosis.
B. Furie: Thrombus formation in vivo: regulation by thiol isomerases.
12:30-1:30 pm Lunch
1:30-3:00 pm VWF in disease
R. Schneppenheim
A. Randi: Von Willebrand factor regulates angiogenesis.
S. De Meyer: Plasmatic coagulation factors in ischemic stroke: pathophysiological role and therapeutic targets.
Z. Ruggeri: Dissecting von Willebrand factor functions in hemostasis and thrombosis.
3:30-5:00 pm Clinical aspects of VWF
J. Rädler
P. Lenting: FVIII/VWF: a highly dynamic relationship
J. Oldenburg: Perspectives of immune tolerance therapy in patients with hemophilia and inhibitors.
J. Rädler: Destabilized recombinant VWF as substrate for highly sensitive ADAMTS13 assays.
5:00-6:30 pm VWF in TTP
U. Budde
R. Schneppenheim: Pathophysiology of VWF.
J. Kremer Hovinga: TTP – the consequence of lacking VWF size regulation.
S. Schneider: The impact of VWF in tumor thrombophilia and progression.

For registration and abstract submission please send the completed REGISTRATION FORM (link below) to:

e-mail: registration@shenc.de or fax +49 (0)40 7410 54601

Your registration will be confirmed once payment is received. In case you choose the on-site payment option (non-EU members only) your registration will be confirmed once registration form is received.

Call for Abstracts
- Abstract Deadline: July 1st 2015
- Please use the registration form to submit your abstract

Preparation of your Abstract
- Abstracts must be submitted in English
- All abstracts must contain original work that has not been published or presented identically on previous occasions
- The title should be as brief as possible but long enough to indicate clearly the nature of the study. Abbreviations must not be used in the title
- Abstract text is limited to 2,500 characters (not including spaces)
- Tables, graphics and photos will not be accepted
- Please check spelling and grammar carefully. All abstracts will be published in the abstract book as submitted
- Use generic names. Commercial drug names may not be used.

Preparation of your Poster:
- Posters shall be prepared in portrait format, in English language.
- The size of the poster boards will be height x width = 55’’ x 46’’ (Höhe x Breite = 140 cm  x 117 cm ).

We are looking forward to meeting you in Hamburg!
With kind regards,

Dr. Maria A. Brehm and Dr. Ulrike Klemm
Organizing committee
  (DOCX)   (PDF)  
  Professionals 200 € / Students 50 € (on-site payment for non-EU members only!)  
  (PDF, Klick for download)  
  From the airport: MetroLine from Station "Hamburg Airport" to Station "Landungsbrücken" (31 min, 3,10 € One-Way)  / 8 min Walk  
  From the airport: Taxi (lower level only) to the hotel (ca. 30 to 40 min on weekends up to 1 hour weekdays)  
  From the Main Station: Metro-Line / to Station "Landungsbrücken" or Station "St.Pauli" (5 min, 1,50 € One-Way)  / 8 min Walk  
  From the Main Station: Taxi (North-End, both sides) to the hotel (ca. 10 to 15 min on weekends up to 30 min weekdays)  
  Arriving by car: Use navigation system! / many construction zones in the city area / main roads closed / many traffic delays all day long  
  Hamburg Transit System: HERE (complete plan, 700 kB, PDF)